Home
Research
Treatments
Business
Management
Contact Us
Delivery of dietary fat from the intestine is a complex process, but chylomicrons as fat carriers play essential roles (see Figure). ZKPr1 binds to chylomicrons and, thus, may interfere with delivery of triglycerides to fat stores. It is possible that the visceral fat adipose tissue gets filled up first with triglycerides followed by subcutaneous fat. Accordingly, visceral fat would be more sensitive to the inhibitory action of low dose ZKPr1 (0.04-0.1 mg/mouse), used either by oral or injection methods, than subcutaneous fat stores. This hypothesis is supported by findings that higher doses of ZKPr1 (0.5 mg/mouse) also inhibit accumulation of subcutaneous fat, thus, reducing “general obesity”. Research is focusing on this plausible scenario.
Ongoing research is using ZKPr1 and ZKPr2 in specific animal models of various health disorders to further confirm, or deny, causal relationships between excess visceral fat and various health disorders including those already suggested, but not firmly established, by human observational studies. Such a relationship is specifically dependent on visceral fat, and not general obesity, only if both proteins substantially (at least 75% or more) reduce excess visceral fat, without statistically significantly affecting body weight, associated with proportional effects on the disorders and physiological conditions, suggested but not definitely proven by observational studies, as indicated with the partial list below:
1. In the human circulation ZKPr1 half-life time is 7 to 10 days allowing once a week or once biweekly applications via systemic or oral routes.
2. It is resistant to proteases which explains its long half-life time in the circulation.
3. It is heat-resistant up to 65 Celsius and is also very stable (for months) at 4 Celsius which makes storage and transport convenient.
The company’s recent finding that in mouse models ZKPr1 specifically and greatly reduces excess visceral fat at commercially attainable and profitable doses, coupled with its stability and nontoxicity, makes it eminently qualified to become a successful drug for a similar and several other human applications.